Impaired Skeletal Muscle Blood Flow Control With Advancing Age in Humans

Impaired skeletal muscle blood flow control with advancing age in humans: attenuated ATP release and local vasodilation during erythrocyte deoxygenation.

RATIONALE Skeletal muscle blood flow is coupled with the oxygenation state of hemoglobin in young adults, whereby the erythrocyte functions as an oxygen sensor and releases ATP during deoxygenation to evoke vasodilation. Whether this function is impaired in humans of advanced age is unknown. OBJECTIVE To test the hypothesis that older adults demonstrate impaired muscle blood flow and lower in...

Clinical/Translational Research Impaired Skeletal Muscle Blood Flow Control With Advancing Age in Humans Attenuated ATP Release and Local Vasodilation During Erythrocyte Deoxygenation

Role of 1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age

Wray DW, Nishiyama SK, Richardson RS. Role of 1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age. Am J Physiol Heart Circ Physiol 296: H497–H504, 2009. First published December 5, 2008; doi:10.1152/ajpheart.01016.2008.— 1-Adrenergic vasoconstriction during dynamic leg exercise is diminished in younger individuals, although the extent of this exercis...

Role of resistance training with the approach of blood flow restriction in skeletal muscle cell growth

Background: The aim of this study was to investigate the response of ERK1/2 protein and muscular morphological adaptations to a period of resistance training with local blood flow restriction. Materials and methods: Twenty healthy male Wistar rats without clinically evident disease (5 weeks old, 120±7 g weight) were divided into four equal groups: control, control with limited blood flow...

Role of {alpha}1-adrenergic vasoconstriction in the regulation of skeletal muscle blood flow with advancing age.

alpha(1)-Adrenergic vasoconstriction during dynamic leg exercise is diminished in younger individuals, although the extent of this exercise-induced "sympatholysis" in the elderly remains uncertain. Thus, in nine young (25 +/- 1 yr) and six older (72 +/- 2 yr) healthy volunteers, we evaluated changes in leg blood flow (ultrasound Doppler) during blood flow-adjusted intra-arterial infusion of phe...